![]() ![]() In contrast, pathological hypertrophy, a decompensated stage with complex network of cellular and molecular regulation, usually observed in patients with long-term cardiovascular disorders, is accompanied by cardiac systolic/diastolic dysfunction and the enlargement of CMs is often irreversible ( 3, 4). Physiological hypertrophy, which usually occurs during pregnancy and exercise, is characterize with a coordinated increase in ventricular volume and wall thickness, most importantly, it is reversible once the stimulus was relieved ( 2). Cardiac hypertrophy can be generally divided into physiological and pathological hypertrophy. Therefore, in adult hearts, CMs have no capability of proliferating in response to prolonged pressure/volume overload instead, they exhibit morphological enlargement to continuously pump blood to provide oxygen and nutrients to the body, thus leading to the increased heart wall thickness and heart mass, and eventually cardiac hypertrophy ( 1). Our article is also to summarize the strategies of mitochondria-targeting as therapeutic targets to treat cardiac hypertrophy.Ĭardiomyocytes (CMs) are one of the most important cell types which become terminally differentiated once after birth. This article presents a summary review of the morphological and functional changes of mitochondria during the hypertrophic response, followed by an overview of the latest research progress on the significant modulatory roles of mitochondria in cardiac hypertrophy. The significant alterations in mitochondrial energetics and mitochondrial proteome composition, as well as the altered expression of transcripts that have an impact on mitochondrial structure and function, may contribute to the initiation and progression of cardiac hypertrophy. In recent years, accumulating evidence has indicated that mitochondrial dysfunction is implicated in pathological cardiac hypertrophy. Sustained cardiac overload inevitably results in high energy consumption, thus breaking the balance between mitochondrial energy supply and cardiac energy demand. ![]() 3Department of Thyroid and Breast, Renmin Hospital of Wuhan University, Wuhan, ChinaĬardiac hypertrophy, a stereotypic cardiac response to increased workload, ultimately progresses to severe contractile dysfunction and uncompensated heart failure without appropriate intervention.2Hubei Key Laboratory of Metabolic and Chronic Diseases, Wuhan, China.1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.Dan Yang 1,2 †, Han-Qing Liu 3 †, Fang-Yuan Liu 1,2, Zhen Guo 1,2, Peng An 1,2, Ming-Yu Wang 1,2, Zheng Yang 1,2, Di Fan 1,2 * and Qi-Zhu Tang 1,2 * ![]()
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![]() ![]() The password generator also includes a password history where you can view previous passwords that Dashlane generated - quite handy if you forget to save a newly generated password to your vault. This customizable identity-filling process makes it super easy to auto-fill even the most complex web forms.ĭashlane’s password generator can create passwords between 4 to 40 characters long that contain a mix of letters, numbers, and symbols. You can customize each identity to match the type and format of documents for the country of your choice, and you have various templates to choose from - such as person, address, passport, and more. However, I was really impressed with the level of customization that RoboForm provides whenever you’re creating an identity. Personal and payment information storage.īoth password managers have great auto-save and auto-fill functionalities and performed well in my tests - saving and auto-filling my personal details, including name, phone number, address, and bank account details on various sites.Dashlane is also incorporating passwordless login - which will be an excellent way to not have to worry about losing your master password when it fully rolls out.ĭashlane and RoboForm both offer a comprehensive set of basic password management features, which include: One standout feature of Dashlane that RoboForm lacks is its support for passkeys - an efficient and secure way of accessing accounts without having to create or remember complex passwords. While Dashlane supports 2FA via biometric scanning and TOTP authenticator apps like Google Authenticator and Authy, RoboForm extends its 2FA support to include SMS codes. However, in terms of 2FA options, RoboForm offers more variety than Dashlane. That said, it’s great that Dashlane offers a way to recover your account if you ever lose your master password - RoboForm doesn’t provide any account recovery methods. I’d have preferred it if Dashlane provided more convenient account recovery options like SMS or one-time password recovery. However, in order to use this function, you have to have set up biometric logins on at least one of your devices that supports fingerprint or face ID verification first. I like how Dashlane provides account recovery via biometrics, allowing you to reset your master password from the mobile app if you ever forget it. Two-factor authentication (2FA) - An additional layer of security that requires two forms of identification to log into your password vault.Zero-knowledge protocol - This means neither Dashlane nor RoboForm employees can access the data stored in your password vault.It’s never been broken and is the same standard used by banks and the military. 256-bit AES encryption - This encryption standard ensures your data is safe.(Biometrics on mobile or backup codes as a 2FA alternative)ĭashlane and RoboForm are both highly secure password managers, each offering several core security features such as: New device logins require email code confirmation (TOTP, email verification on new devices) TRY DASHLANE TODAY Security & Data Privacy - Dashlane Provides Stronger Security Live chat, email support, phone support, knowledge base, Twitter and Reddit supportĮmail support, live chat, phone support, help center, PDF manual Windows, Android, Mac, iOS, Linux, ChromeOSĬhrome, Firefox, Edge, Safari, Opera, Brave Windows, Mac, Linux, ChromeOS, iOS, Android Zero-knowledge architecture Multiple 2FA options I encourage you to read on to see which password manager would best fit your needs. ![]() However, my testing ultimately revealed Dashlane as the better option due to its extensive feature set. ![]() ![]() It was a tight contest, as both products offer unique features and benefits. To determine the better password manager, I spent several weeks testing them both, evaluating their respective security features, pricing structures, ease of use, and customer support. Dashlane, for example, is the only password manager that comes with a VPN, while RoboForm offers secure bookmark storage and the ability to auto-save and auto-fill passwords for Windows apps. Key features common to both Dashlane and RoboForm include:īut Dashlane and RoboForm also distinguish themselves with unique offerings. Also, they both offer free plans, with Dashlane’s free plan providing a slightly broader range of features than RoboForm’s. Dashlane is a high-quality password manager with standout features like passkey support and unique extras like a VPN and real-time dark web monitoring.ĭashlane and RoboForm stand out as two of the best password managers in 2023 - each providing top-tier security features and intuitive apps. ![]() ![]() In-stock orders received by 12:00 PM Eastern Time Monday-Friday will usually ship same day. Eligibility varies by location of item, availability, and the shipping address zip code. The shipping cost of machines (vacuum cleaners, fans, heaters, humidifiers, purifiers, hair dryers, and lighting) is free of charge when ordering on for select zip codes. Please allow 1-2 business days for order processing. Lower price will not be honored if the result of a violation of a Dyson unilateral advertising or pricing policy or if doing so would result in a violation of a Dyson policy. ĭyson reserves the right to rescind this offer at any time and/or modify these terms and conditions as needed.Hair care machine and accessories, which include, but are not limited to, the Dyson Supersonic™, Dyson Airwrap™, and Dyson Corrale™, are not eligible for price matching..Machine price must not be lower due to an advertising error or misprint.It cannot be used, damaged, returned, open box, "close out", "clearance" or a demonstrator machine. Machine must be new and in original packaging.Excludes third party marketplace sellers other than Dyson. Authorized refurbished machine dealers are limited to Nordstrom Rack, Woot and Zulily. Authorized new product dealers are limited to Best Buy, Costco, Bed Bath & Beyond, Home Depot, Lowes, QVC, Sam's Club, and Target.Advertised price must be the listed price membership/loyalty, promo code entries or like discounts are not eligible for price matching). ![]() Proof of advertised price by an authorized dealer is required (Valid copy of flyer or website URL required.To locate the serial number on your product, please visit /serial-number-help for location details by specific machine. You can identify the machine serial number on the box or on the product itself. Machine must be the exact same model number as it appears on and in stock.Here are the details you need to know: Visit /pricematch, the chatbox on, or contact our Customer Service team at 1-86 to get started. If within 30 days of purchase you should find the same model currently advertised at a lower price by an authorized US Dyson retailer or by Dyson on a third party marketplace site, we'll refund you the difference if the below details are satisfied. Be confident that you’re getting the best price on. ![]() ![]() ![]() I also tried using -map 0:v and -c:0:v instead of usinst just -v, but this threw an "Invalid stream specifier" error. master_pl_name test.m3u8 -hls_segment_filename. hls_flags append_list -hls_playlist_type event -hls_start_number_source generic -start_number 0 \ ![]() var_stream_map "v:0,agroup:audio,ccgroup:cc a:0,agroup:audio,language:ger,ccgroup:cc a:1,agroup:audio,language:eng,ccgroup:cc a:2,agroup:audio,language:fra,ccgroup:cc a:3,agroup:audio,language:spa,ccgroup:cc" \ cc_stream_map "ccgroup:cc,instreamid:CC1,language:ger ccgroup:cc,instreamid:CC2,language:eng ccgroup:cc,instreamid:CC3,language:fra ccgroup:cc,instreamid:CC4,language:spa" \ i LFS_000420_heidelberg4sprachen_spa.vtt \ i LFS_000420_heidelberg4sprachen_fra.vtt \ i LFS_000420_heidelberg4sprachen_eng.vtt \ i LFS_000420_heidelberg4sprachen_ger.vtt \ Here's what I've been trying to do: ffmpeg -i LFS_000420_heidelberg4sprachen.mp4 \ Mapping the separate vtt files into the mix doesn't seem to work. This works fine, including different variant streams for the languages. I'm resizing the file and turning it into transport segments and the HLS playlists using the HLS muxer of FFmpeg 4.2 (Version from the Fedora 32 repos). I also have 4 subtitle tracks in WebVTT format, one per language.My main file is containing a single video track and 4 audio tracks, both in different languages.I've been experimenting with adding WebVTT subtitles to an HLS playlist, but I'm starting to ask myself if what I'm trying to do is actually possible. ![]() ![]() ![]() I found this roguelike mechanic to be well-done once I got accustomed to it, but it’s not clearly explained.Īfter each boss fight is an option to forge ahead or return to a hub where Tama can improve her weapons and swap out items to increase her chances of success. However, be warned - if she dies, it’s back to the start of the dungeon, with all accrued items and half her levels lost. Along the way, she’ll level up, acquire stronger weapons, forage for health, and fight some disturbingly frightening bosses. Gameplay has Tama venturing into a series of rooms littered with enemies and traps, attempting to reach the depths of the dungeon. Necromancer is certainly focused more on combat than story, but it made me care about their heartbreaking tale nevertheless. This lesbian relationship feels authentic and earnest, and Seeing Koko and Tama evolve from begrudging co-workers to devoted partners is a treat - which makes it even more heartbreaking to eventually learn the cause of Koko’s death. The character development is surprisingly strong presented in lovely, pixelated vignettes and the voice acting is beautifully expressive. The game follows the story of Tama, a soldier venturing into an unknown dungeon with the hopes of bringing her deceased lover, Koko, back to life with the help of the mysterious Sword of the Necromancer. Sword of the Necromancer’s story drew me in from the start. It’s a small experience that can get repetitive at times, but I appreciated its unexpected levels of heart. However, it’s soon revealed to contain a mix of various elements that elevate it into being a pleasant little package. ![]() WTF The sword’s lore is unexpectedly dark and creepy.Īt first glance, Grimorio of Games’ newest title, Sword of the Necromancer, seems like a typical top-down roguelike dungeon crawler. LOW The restart mechanic was not explained well. HI GH The plot is surprisingly heartfelt. ![]() ![]() ![]() Over the years it has moved locations and is now on the waterfront near Pier 23. Halifax is home to the oldest continuously operating farmer’s market in North America. So grab a book, find a cozy spot and stay warm indoors. The fourth floor also has some great views of the city. Open Thursday 2-9pm, Friday – Sunday 10am-5pm 10. Visit the Public LibraryĪnother great spot to spend those chilly winter days is the Halifax Public Library.Įven for those who aren’t book lovers, the architecture of the building stunning (in fact, the building has won a few awards for its architecture). The largest art museum in Atlantic Canada, the Gallery displays a large collection of local art, as well as a collection of folk art including the tiny Maud Lewis House. Stay warm and spend some time inside at the Art Gallery of Nova Scotia. Yes, we may be a bit biased but Dartmouth is an awesome place to explore! 9. Explore the Art Gallery Or take a stroll through Downtown Dartmouth and experience some of the best places to eat and drink in Dartmouth or admire the public art throughout the downtown area. One of the world’s longest boardwalks, it’s a great spot to stroll along, summer or winter.īundle up and grab some change (fare is $2.75 but your ticket is valid for a return trip within an hour or so) and head over to Dartmouth.Īlderney Landing has a Saturday market, which is right in the ferry terminal. The Halifax Boardwalk is the most visited attraction in Nova Scotia anytime of the year. Sledding is always a popular activity in the winter, but in Halifax, you’ve got to try sledding down Citadel Hill!Ĭitadel Hill is considered one of the top tobogganing hills in Canada, and once you see it, you’ll understand why! For more places to go sledding in Halifax, check out this post here. Open 8am to 4pm daily, and evenings in November and December for the Holiday Light display. The paths are well maintained and it’s a great spot to get away from the city and enjoy the quiet winter scenery. Right in the heart of downtown Halifax, the Public Gardens are a fantastic place to wander through year round. It’s a great way to get outdoors and enjoy the winter weather!įun fact: The Emera Oval is the largest outdoor artificially refrigerated There are no lockers though so bring a tote bag to store your boots or shoes in. Skate and helmet rentals are free to rent (with gov’t ID provided).Īll children 12 and under must wear a helmet – you can bring your own or rent one there. ![]() ![]() Within this wealth of technological innovation K’s holographic girlfriend Joi (Ana de Armas) presents the greatest extension of Blade Runners’ central question – what is it to be human? With a strong resemblance to Spike Jonze’s superb Her, Joi ambiguously straddles a life between human-esq sentience and merely servicing the subconscious desires of K. Ana Stelline (Carla Juri) crafts virtual reality memories to implant in Replicants, chillingly calling into question the validity of our own history and memory. In another instance of pure inspiration, the imprisoned Dr. In one of the film’s standout set-pieces a fistfight unfurls within one of Las Vegas’ derelict bars with distorted holograms of Liberace, Elvis and Marylin Monroe ghosting through the backdrop. Villeneuve’s achieves this disorienting spectacle through an obsessive attention to detail and a wealth of inspired designs anchored in 2017’s technological innovations. Veteran cinematographer Roger Deakins imbues these varied locations with their own vivid, breath-taking essences that glow, shimmer and sprawl with supreme authenticity.Ģ049’s world building is a dizzying experience capable of lulling us into questioning our own understanding of what is real and what is not. K’s mission takes him away from the claustrophobic alleys and into the remains of California sterile plains, the industrial dumping grounds of San Diego, an abandoned Las Vegas coated in an eradiated orange haze and Wallace Corporation’s Feng Shui blend of wood, water and shadows. If Blade Runner’s ‘cyber punk’ vision was anchored around the idea of cramped and dehumanising urbanisation, then 2049 is centred around alienation and isolation. Scott combined the shadowy underworld of Film Noir, the abrasive fashion of Punk and a parallel America overrun by Asian influence with hectic noddle bars and garish neon glows. The original Blade Runner’s most venerated element was its paradoxically retro-futuristic urban landscape. Joshi (Robin Wright) orders him to find and destroy the mystery child, megalomaniac Replicant manufacture Niander Wallace (Jared Leto) envisions the miracle child as the key to his ambitious plans. On Morton’s farm, K makes a discovery capable of destroying the delicate balance of power between human and Replicant the skeletal remains of a Replicant found to be capable of the seemingly impossible childbirth. The Replicant, Sapper Morton (Dave Bautista), refuses to go quietly, but before K decommissions him Morton goads his killer with a phrase of enigmatic significance “You’ve never seen a miracle”. 2049 opens to K (Ryan Gosling), a replicant ‘blade runner’, encountering an old model Replicant in the charred outskirts of LA. ![]() In the intervening 35 years since Blade Runner little has changed in its dystopian Los Angeles a deluge of rain pounds the Brutalist fragments, Replicants remain ubiquitous and ‘blade runners’ still scour the landscape hunting AWOL androids. Yet instead of constructing a hollow Replicant of its 35 year old predecessor, director Denis Villeneuve has crafted a sequel of staggering visual supremacy and boundless innovation worthy of Ridley Scott’s original vision. In a world of safe uninspired reboots, sequels and spin-offs ready to milk the last drops of worth from their cultural cash cows, Blade Runner 2049, in true noir fashion, felt destined for failure. Familiar blockbuster franchises beamed across the gigantic screen in new guises – Star Wars: The Last Jedi, Thor: Ragnarok and Justice League – barely capable of papering over the tired tropes, numbing action and stale characters. Settling down to view Blade Runner 2049 at the Imax in Manchester, the preceding trailers appeared as a timely reminder of cinematic disappointment. ![]() ![]() ![]() You have successfully downloaded and installed So Player on Firestick using Es File Explorer. Step13: Once installation completes, click on Done. Step12: It will begin installing So Player on Firestick. Step11: Once the download completes, Click on Install. Step10: Download begins and completes within a minute. It just takes only a few steps to complete. Some changes have to be done before sideloading an application on firestick. Just follow the steps below to sideload SO Player on Fire stick in a minute. However So Player is not available on the Amazon App store So, you have to sideload So Player on Firestick. How to Download and Install So Player on Firestick? Player on Firestickĭownloading and Installing an application on firestick is so simple and easy to do it in a minute. So, there is no issue with using So Player for firestick. It does not provide any Streaming content on its own. ![]() Actually So Player is just a platform to watch the streaming content. So Player just acts as a middleware for IPTV/OTT Platform. However, It does not provide any Streaming content like Television shows, Movies, Radio Channels, VOD, and much more. So Player is a free application available on the Internet that provides a platform to watch Streaming Content. Video Tutorial to Install So Player on Firestick.How to Setup So Player on Firestick/Fire TV?.Method 2: How to Download and Install So Player on Firestick using Es File Explorer?.Method 1: How to Download SO Player on Firestick using Downloader App?.How to Download and Install So Player on Firestick?. ![]() ![]() ![]() ![]() Water in cakes serves to make the batter as thin as possible, the better to allow bubbles-responsible for a cake's fluffiness-to form. Despite its descent from cakes and other sweetened breads, the cookie in almost all its forms has abandoned water as a medium for cohesion. Cookies are produced in a wide variety of styles, using an array of ingredients including sugars, spices, chocolate, butter, peanut butter, nuts, or dried fruits.Ī general theory of cookies may be formulated in the following way. Other types of cookies are not baked at all, such as varieties of peanut butter cookies that use solidified chocolate rather than set eggs and wheat gluten as a binder. DescriptionĬookies are most commonly baked until crisp or else for just long enough to ensure soft interior. There was much trade and cultural contact across the North Sea between the Low Countries and Scotland during the Middle Ages, which can also be seen in the history of curling and, perhaps, golf. Īccording to the Scottish National Dictionary, its Scottish name derives from the diminutive form (+ suffix -ie) of the word cook, giving the Middle Scots cookie, cooky or cu(c)kie. Another claim is that the American name derives from the Dutch word koekje or more precisely its informal, dialect variant koekie which means little cake, and arrived in American English with the Dutch settlement of New Netherland, in the early 1600s. The American use is derived from Dutch koekje "little cake," which is a diminutive of "koek" ("cake"), which came from the Middle Dutch word "koke". ![]() From 1808, the word "cookie" is attested ".in the sense of "small, flat, sweet cake" in American English. The word cookie dates from at least 1701 in Scottish usage where the word meant "plain bun", rather than thin baked good, and so it is not certain whether it is the same word. Ĭookies that are baked as a solid layer on a sheet pan and then cut, rather than being baked as individual pieces, are called in British English bar cookies or traybakes. In Scotland the term "cookie" is sometimes used to describe a plain bun. The container used to store cookies may be called a cookie jar. However, in many regions both terms are used. The term "cookie" is normally used to describe chewier ones. In many English-speaking countries outside North America, including the United Kingdom, the most common word for a crisp cookie is " biscuit". Traditional American Christmas cookie tray Fresh-baked cookies are sold at bakeries and coffeehouses. Factory-made cookies are sold in grocery stores, convenience stores and vending machines. Cookies are often served with beverages such as milk, coffee or tea and sometimes dunked, an approach which releases more flavour from confections by dissolving the sugars, while also softening their texture. Some cookies may also be named by their shape, such as date squares or bars.īiscuit or cookie variants include sandwich biscuits, such as custard creams, Jammie Dodgers, Bourbons and Oreos, with marshmallow or jam filling and sometimes dipped in chocolate or another sweet coating. Chewier biscuits are sometimes called "cookies" even in the United Kingdom. Most English-speaking countries call crunchy cookies " biscuits", except for the United States and Canada, where " biscuit" refers to a type of quick bread. It may include other ingredients such as raisins, oats, chocolate chips, nuts, etc. It usually contains flour, sugar, egg, and some type of oil, fat, or butter. A cookie ( American English), or a biscuit ( British English), is a baked or cooked snack or dessert that is typically small, flat and sweet. ![]() |